All‐TRANS, 13‐CIS and 9‐CIS retinoic acids induce a fully reversible growth inhibition in HNSCC cell lines: Implications for in vivo retinoic acid use
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Combined staurosporine and retinoic acid induces differentiation in retinoic acid resistant acute promyelocytic leukemia cell lines
All-trans retinoic acid (ATRA) resistance has been a critical problem in acute promyelocytic leukemia (APL) relapsed patients. In ATRA resistant APL cell lines NB4-R1 and NB4-R2, the combination of staurosporine and ATRA synergized to trigger differentiation accompanied by significantly enhanced protein level of CCAAT/enhancer binding protein ε (C/EBPε) and C/EBPβ as well as the phosphorylation...
متن کاملAcid-Induced Inhibition of NIH-3T3 Cell Growth Construct Reduces Retinoic Acid Metabolism and Retinoic Expression of a Dominant-Negative Retinoic Acid Receptor
We have previously reported an unexpected relationship between retinoic acid-induced inhibition of cell growth and the ability of various cell lines to metabolize the retinoid. Here, we report that stable expression of the truncated retinole acid receptor RARa403, transduced in NIH-3T3 cells by a retroviral vector, rendered the cells resistant to retinole acid for growth inhibition and reduced ...
متن کاملExpression of a dominant-negative retinoic acid receptor construct reduces retinoic acid metabolism and retinoic acid-induced inhibition of NIH-3T3 cell growth.
We have previously reported an unexpected relationship between retinoic acid-induced inhibition of cell growth and the ability of various cell lines to metabolize the retinoid. Here, we report that stable expression of the truncated retinoic acid receptor RAR alpha403, transduced in NIH-3T3 cells by a retroviral vector, rendered the cells resistant to retinoic acid for growth inhibition and red...
متن کاملThe Effect of Retinoic Acid on Seminal Vesicle Epithelial Cell
Purpose: The seminal vesicles are androgen dependent exocrine glands producing protein-rich secretion. The retinoic acid has been implicated as a signaling molecule for the seminal vesicle development. In the present study, the effect of retinoic acid on seminal vesicle epithelial cell of neonatal mouse was investigated. Materials and Methods: Newborn male N-MRI mice were injected intraperiton...
متن کاملIn vivo inhibition of angiogenesis and induction of apoptosis by retinoic acid in squamous cell carcinoma.
Retinoids inhibit the growth and reverse aberrant differentiation of squamous cell carcinoma (SCC) cells in vitro. To investigate the potential mechanisms of antitumor activity of retinoids in vivo, we used the cervical SCC cell line ME-180 as a s.c. tumor xenograft in athymic nude mice. After s.c. injection, tumor cells were allowed to form visible tumors and antitumor activity of all-trans-re...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 1997
ISSN: 0020-7136,1097-0215
DOI: 10.1002/(sici)1097-0215(19970117)70:2<194::aid-ijc10>3.3.co;2-d